Anti-Angiogenic Therapeutic Indicators in Breast Cancer
Abstract
This is an IDEA award to study the therapeutic indicators for anti-angiogenic therapy. In vitro and in vivo strategies will be used to measure treatment efficacy of anti-angiogenic compounds in order to facilitate their clinical development. Dynamic contrast enhanced MRI can be applied to measure vascular changes after therapy. We will also study the immunohistochemical angiogenic biomarkers in tumor tissues before and after therapy. During Yr-O1 we studied R323O AC mammary tumors treated with Taxotere. The treatment did not cause shrinkage of the tumor, rather only slowing down the growth rate. The large size contrast agent Gadomer-17 could detect a reduced vascularity in responders compared to controls. We are also working on developments of immunohistochemical staining procedures for rat tissues. Using available specimens of ENU induced tumors, we stained p53, TSP-17, Factor VIII, and VEGF. The data showed that all ENU induced tumors had wild type p53. The Factor VIII vessel density showed significance differences between malignant and benign tumors. In Yr-02 we will continue the study to treat ENU induced tumors with anti- angiogenic therapeutic agents. All methods to be used in this study have been developed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA410093
Entities
People
- Min-ying L. Su
Organizations
- University of California, Irvine