Differential Processing of Cyclin E Variants in Normal Versus Tumor Cells and Their Role in Breast Cancer Oncogenesis
Abstract
Cyclin E is a positive regulator, which controls the transition of the G1 to S phase of the cell cycle. When associated with CDK2, it is responsible for cells passing through the restriction point, which is the barrier between G1 and S. This commits the cell to complete one round of cell division. Previous findings by this laboratory have found that overexpression of cyclin E and the presence of lower molecular weight isoforms (LMW) are found more often in breast tumors and cancer cell lines when compared to normal tissues and cells. Also, tumor cells, but not normal cells have the mechanisms to proteolytically cleave the full length cyclin E into these LMW forms. An altered cyclin E may contribute to the deregulation of the G1 to S checkpoint and lead to tumorigenesis. Our laboratory has also identified through mutational and biochemical analysis, the region of cyclin E that is proteolyticaly cleaved to generate the LMW forms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA410125
Entities
People
- Khandan Keyomarsi
- Mollianne J. Mcgahren
Organizations
- The University of Texas MD Anderson Cancer Center