1 A-Hydroxyvitamin D5 as a Chemotherapeutic and Possibly Chemopreventive Agent
Abstract
We identified a novel vitamin D analog, 1 alpha-hydroxy-24 ethyl vitamin D5 (1 alpha(OH)D5) that showed potent growth inhibitory and cell-differentiating actions in breast cancer cells. Based on our findings in vitro and in vivo, we hypothesized hat 1 alpha (OH)D5 (D5), when administered to women with breast cancer, will induce differentiation of dedifferentiated cells and thereby prevent progression of malignancy. 1999-2000, we completed preclinical studies in rats, showing that D5 has no serious toxicity; a hypercalcemia effect was observed at high dose, which was reversible. In vitro study in tissues obtained from patients show that D5 has no effect on normal breast epithelial cells but induces apoptosis in breast cancer and showed apoptotic effect in fibroadenomas.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA410172
Entities
People
- Tapas K. Dasgupta
Organizations
- University of Illinois at Chicago