Novel Drug Delivery Technique for Breast Cancer Therapy
Abstract
This report describes the progress achieved during the first year of the project. We proposed to implement Task 1 (a and b) and Task 2a in the first year of the project. Task 1 (a and b) focuses on in vivo studies of ultrasound-induced penetration of model (fluorescent) anti-cancer drugs in human MCF-7 breast tumors of nude mice. Task 2a is devoted to in vivo studies of ultrasound-induced penetration of real anti-cancer drug 5-FU in the breast tumors. We conducted these studies to implement the proposed tasks. Our data obtained with regular and fluorescence microscopy indicate that the ultrasound produces enhanced delivery of model and real anti-cancer drugs in the tumors. We demonstrated increased penetration of the fluorescent anti-cancer drug from blood into ultrasound- irradiated tumors compared with control (non-irradiated) tumors. Dramatic tumor necrosis was obtained when mice injected with real anti-cancer drug and the tumors were irradiated by ultrasound, while no tumor necrosis was noticed when the drug was used without irradiation. Our data suggest that the proposed novel technique may improve efficacy of breast cancer chemotherapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA410175
Entities
People
- Rinat O. Esenaliev
Organizations
- University of Texas Medical Branch