Heat Shock Protein 27 Inhibits Apoptosis by Binding Cytochrome C

Abstract

The purpose of this research project is to investigate the interaction between heat shock protein 27 (hsp27) and cytochrome c in the inhibition of apoptosis. The scope of the study will include: measuring the binding of hsp27to cytochrome c in vivo, determining why hsp27 binds to cytochrome c and determining the fate of the hsp27:cytochrome c complex. Major findings to date include: cellular survival cures to cytochrome c and molecular chaperone assays with hsp27 and citrate synthase and alpha-glucosidase. A no-cost one year time extension was granted to complete the goals of the project.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA410188

Entities

People

  • Stephen W. Carper

Organizations

  • University of Nevada, Las Vegas

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Classification
  • Cytochromes
  • Electronic Mail
  • Information Operations
  • Inhibition
  • Macromolecules
  • Molecules
  • Neoplasms
  • Proteins
  • Security
  • Survival

Fields of Study

  • Biology
  • Computer science

Readers

  • Immunology and Pathology
  • Molecular and genetic basis of cancer.