Molecular Mechanism for Loss of Cell Adhesion in HER-2/neu Overexpressing Tumor Cells
Abstract
Introduction The HER-21/neu proto-oncogene is amplified and overexpressed in 25% of breast cancers. In animal models and in the human disease overexpression of this membrane receptor protein is considered to play a pathogenic role in the disease process. Clinically, overexpression is correlated with a shorter disease-free interval and a shorter overall survival of women with breast cancer. Overexpression is also correlated with lack of responsiveness to tamoxifen anti-hormone therapy and responsiveness to selected forms of chemotherapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA410189
Entities
People
- Michael F. Press
Organizations
- University of Southern California