Signal Transduction in Prostate Cancer
Abstract
The goal of this Prostate Cancer Center Initiation Award is to examine signal transduction pathways involved in prostate cancer progression, with an eye toward translational research applications. The program has two Projects and a Core Animal Facility. The first project (Dr. Carey) is focused on crosstalk between receptor tyrosine kinases and the androgen receptor (AR), using the Her2/neu kinase as a model system. Progress in the second year includes the completion of preclinical studies with an EGFR/Her2-neu kinase inhibitor with new, unexpected insights about the clinical application of these drugs. During year 3, we anticipate further progress toward a better understanding of AR crosstalk and developing imaging technologies to follow disease progression in mouse models. The second project (Dr. Cohen) examines the role of IGF binding protein 3 (IGFBP-3) in the context of crosstalk with the retinoic acid co-receptor RXR alpha. Progress to date confirms that IGFBP-3 induces apoptosis in synergistic fashion with RXR ligands in multiple prostate models. Year 3 will focus on in vivo studies of IGFBP-3 protein therapy alone and in combination with RXR alpha ligands in mouse models, using the Core facility. Both projects have led to the conception of clinical translational projects that are components of the UCLA Prostate SPORE application scheduled for funding in late 2002.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2002
- Accession Number
- ADA410217
Entities
People
- Charles Sawyers
- Hong Wu
- Michael Carey
- Pinchas Cohen
Organizations
- University of California, Los Angeles