Examination of the Contribution of VEGF to the Metastatic Dissemination of c-Myc Overexpressing Breast Cancer Cells
Abstract
Metastasis to the lung is a common occurrence accounting for approximately 60-70% of metastasis. We have developed a transgenic model of lung metastasis using a MMTV-c-myc/MMTV-VEGF bitransgenic mouse system. We are using this system to evaluate the mechanism by which VEGF is able to dramatically increase metastasis to the lung. In spite of technical difficulties that have resulted in delays in the study, we have made significant progress towards generating the samples required to complete the proposed work and have developed a new series of cell lines for the project. Using these reagents we will evaluate the importance of blood vessel morphology and biology, versus tumor behavior in studies of the determinants of primary tumor intravasation and the estravasation of the shed cells at the site of the establishment of new metastatic deposits. Two papers describing our work will shortly be submitted for publication.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA410255
Entities
People
- Michael D. Johnson
Organizations
- Georgetown University