A Study of Transrectal Tumor Oxygen Measurements in Patients with Clinically Localized Prostate Cancer
Abstract
The primary aim of this clinical study is to determine the relationship between pre-treatment prostate cancer oxygen levels and long-term disease control following treatment with radiotherapy, and the independent prognostic effect of oxygen measurements relative to established prognostic factors. In addition, the study will determine the relationship between pre-treatment tumor oxygen levels and mutations of the p53 tumor suppressor gene, and the impact of this interaction on patient outcome. A total of 40 patients were accrued to the study in year 1. This is below the anticipated accrual of 65 patients per year. Measures have been implemented to increase accrual in year 2, and the ultimate goal of determining the independent prognostic significance of tumor oxygenation in patients with prostate cancer will be achieved. The micro-regional distribution of oxygen in prostate cancer biopsies will be studied using one of the intrinsic markers of oxygenation rather than EF5 as described in the initial proposal. The molecular studies of p53 and apoptosis are proceeding as outlined in the proposal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA410273
Entities
People
- Ants Toi
- David Hedley
- Joan Sweet
- Michael F. Milosevic
- Robert Bristow
Organizations
- University Health Network