Genetic Variation in the HSD3B2 Gene and Prostate Cancer
Abstract
Prostate cancer is the most common cancer in American men. It is also characterized by a substantial racial/ethnic variation in risk: highest in African-American men, lowest in Asian men and intermediate in Caucasian and Latino men. We propose to investigate genetic variants of genes involved in the regulation of prostatic growth and particularly in androgen metabolism, particularly the HSD3B2 gene which encodes the type II b-hydoxysteroid dehydrogenase. Our current progress is highlighted by the following three findings. First, our data indicate that the locus under investigation is polymorphic in constitutional DNA and mutated somatically in tumor tissue. Furthermore, our population-based investigations suggest that at least one polymorphism in the HSD3B2 gene is relatively common and in Hardy-Weinberg equilibrium in our population. Finally, our initial biochemical results point to an interesting regulation of the activity of this bifunctional enzyme.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA410274
Entities
People
- Jeurgen K. Reichardt
Organizations
- University of Southern California