Serum FAS and the Early Detection of Breast Cancer
Abstract
This study will explore the potential usefulness of measuring blood levels of fatty acid synthase (FAS) as a means of breast cancer early detection. Fatty acid synthase (FAS) is associated with poor breast cancer prognosis and is elevated in both breast cancer and in situ disease compared to normal breast tissue. Recently, serum FAS assays have been developed and higher serum FAS levels have been found in women with breast cancer compared cross-sectionally to women without the disease. In this nested case-control study we will analyze FAS levels in blood samples donated in l974 and 1989 by women from Washington County Maryland participating in the CLUE studies. Samples from 129 incident breast cancer cases detected between 1990 and 1998, a like number of women diagnosed with benign breast disease during these same years, and a group of controls not diagnosed with any breast disease will be analyzed. Associations between absolute, and change over time in, serum FAS levels with subsequent breast cancer risk will be estimated as will the ability of these measures to correctly classify women with breast cancer, benign breast disease, and no diagnosed breast disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA410282
Entities
People
- Craig J. Newschaffer
Organizations
- Johns Hopkins University