Cell Motility in Tumor Invasion

Abstract

Our overall objective is to understand how dysregulation of cell migration contributes to tumor cell invasiveness in prostate cancer. A combination of correlative epidemiological studies and basic experimental investigations demonstrate a role for upregulated EGF receptor (EGFR) signaling of motility in tumor progression. BGFR- mediated cell motility has been demonstrated to be critical for tumor invasion. Our central premise is that prostate tumor cell invasiveness can be inhibited by interfering with the specific motility-associated calpain activation that governs the critical underlying biophysicalprocess of de-adhesion. Prior work by ourselves and others has shown that integrin/matrix binding and growth factor stimulation jointly regulate cell locomotion.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA410314

Entities

People

  • Alan Wells
  • Douglas A. Lauffenburger
  • Timothy Turner

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Cell Membrane
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Crystal Structure
  • Cytoskeleton
  • Epithelial Cells
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).
  • Theoretical Analysis.