Adequacy of Chemotherapy Dose Intensity Among African-American Women with HER-2/neu-Positive Breast Cancer

Abstract

The purpose of this study is to investigate the possibility that systematic differences in the quality of adjuvant chemotherapy given to African-American and Caucasian women account for the poorer outcome in African-American women. We will determine the impact of these differences on outcome, particularly in patients whose tumors overexpress HER-2/neu (in whom chemotherapy dose is particularly important) . The analysis described in this report includes 489 subjects (109 African-American and 380 non-Hispanic Caucasian) who received adjuvant chemotherapy between 1985 - 1995 in two geographical locations. Chemotherapy dose proportion (actual/predicted doses) and dose intensity were determined for each drug and for the regimen. Using multivariate regression models, we have demonstrated that African- American ethnicity is an independent predictor of lower dose proportion and dose intensity (correcting for sociodemographic, tumor characteristics, and treatment course).

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA410338

Entities

People

  • Jennifer J. Griggs

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Abstracts
  • African Americans
  • Breast Cancer
  • Cell Count
  • Chemotherapy
  • Data Analysis
  • Databases
  • Diseases And Disorders
  • Drug Therapy
  • Ethnic Groups
  • Health Services
  • Intensity
  • Medical Personnel
  • Minority Groups
  • Neoplasms
  • Physicians
  • Therapy

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