DNA Damage, Fruits and Vegetables and Breast Cancer Prevention

Abstract

The purpose of this project is to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer. The rationale that underlies the work proposed is based on evidence that the occurrence of DNA mutations are essential steps in carcinogenesis and that these mutagenic events can result from oxidative stress, even in the absence of exogenous carcinogens. The effects of consuming a recipe-defined diet designed to provide three (control) or ten (intervention) servings of fruits and vegetables per day for a total of 8 weeks on measures of oxidative damage to DNA and lipids is being determined. During this reporting period, the accrual goal of enrolling 200 subjects in this project was exceeded. A total of 213 individuals completed the dietary intervention. Sample analysis is complete and of data evaluation is now ongoing and will be finished during the one-year no cost extension of this project.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2002
Accession Number
ADA410386

Entities

People

  • Henry J. Thompson

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood Proteins
  • Breast Cancer
  • Cancer
  • Carcinogens
  • Chemical Synthesis
  • Chemistry
  • Escherichia Coli
  • Food
  • Intervention
  • Mutations
  • Neoplasms
  • Oxidative Stress
  • Statistical Analysis
  • Test And Evaluation
  • Vegetables

Readers

  • Gender and Food Studies
  • Toxicology/Environmental Toxicology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.