Hormonal Contraception, Body Water Balance and Thermoregulation

Abstract

To test the hypothesis that estrogen (E2) enhanced water and sodium retention, we compared the fluid regulatory responses to exercise-induced dehydration and hypertonic saline infusion(HSI). Studies were conducted during the early follicular and midluteal phases of the menstrual cycle, and following treatment with an estrogen/progestin (OCEP) and a progestin-only (OCP) oral contraceptive in a single blind, randomized, cross-over design. We found a downward shift in osmotic regulation of arginine vasopressin (AVP) during the luteal phase and OCEP compared to the follicular phase during exercise. Similarly, HSI, osmotic regulation of PAvP and thirst were reduced during OCEP and the luteal phase within women. There was little hormonal effect on body water or sodium regulation during exercise or HSI.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA410450

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  • Nina Stachenfeld

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  • Biomedical

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  • Blood
  • Blood Volume
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  • Cardiovascular Diseases
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  • Pituitary And Hypothalamic Hormones And Analogues
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