Electrophysiological Changes in NF1

Abstract

We submitted a manuscript based on the findings from the second year of the grant (Fieber et al). We discovered a component of tumor K current called Ca2+-activated K current. We believe this is the current component that induces proliferation in NF1 Schwann cells (SC). Thus our experimental objectives during the third year of the project were to identify Ca2+-activated K current 5 in SC from our different NF1 cultures and to test the effects on cell proliferation of blocking these currents. A specific blocker of this subtype of Ca2+-activated K current blocked an average 35 + 17% of the current of malignant peripheral nerve sheath tumor (MPNST) SC.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA410453

Entities

People

  • Lynne A. Fieber

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical Research
  • Blood
  • Cancer
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Culture Techniques
  • Lymphocytes
  • Marine Biology
  • Nervous System
  • Neuroglia
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Tissue Donors

Readers

  • Electrical Engineering
  • Molecular and Cellular Biology
  • Neuroscience