Burst Analysis of Chemically Stimulated Spinal Cord Neuronal Networks Cultured on Microelectrode Arrays

Abstract

Planar microelectrode arrays allow the recording of the electrophysiological activity of cultured neurons for long time periods and from different sites of the network. In the developing Central Nervous System, several neural networks are spontaneously active and show a typical high frequency activity pattern called burst. Such behavior seems to play an important role in subsequent maturation. Here we analyze how the bursting electrophysiological activity of cultured spinal cord neurons (14 - 18 DIV) from the chick embryo is affected by cyclothiazide (CTZ) which acts on AMPA receptors. Changes in the patterns of electrophysiological activity are described in detail.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA410479

Entities

People

  • F. Davide
  • M. B. Tedesco
  • M. Chiappalone
  • M. Grattarola
  • S. Martinoia

Organizations

  • University of Genoa

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Algorithms
  • Amplitude
  • Central Nervous System
  • Culture Techniques
  • Data Management
  • Detection
  • Engineering
  • Information Science
  • Intervals
  • Microelectrodes
  • Nervous System
  • Signal Processing
  • Spinal Cord
  • Spreadsheet Software
  • Standards
  • Statistical Analysis

Readers

  • Neuroscience

Technology Areas

  • AI & ML
  • AI & ML - Neural Networks