Small-Field Angiographic Imaging of Tumor Blood Vessels Using Synchrotron Radiation

Abstract

Microangiography with about 10 microns resolution has been carried out for depicting angiogenic vessels in a rabbit IT model of cancer using a high-resolution detector and a third generation synchrotron radiation source at SPring-8. In a synchrotron radiation radiography, a long source-to-object distance and a small source spot can produce high-resolution images. VX2 carcinoma had been transplanted in a rabbit auricle. By using this imaging system, small tumor blood vessels with diameters of 20-30 microns in an immature vascular network produced by angiogenesis were visualized after contrast material injection to the auricular artery.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA410505

Entities

People

  • K. Umetani
  • N. Maehara
  • S. Imai
  • T. Yamashita
  • Y. Kajihara

Organizations

  • Kawasaki Medical School

Tags

Communities of Interest

  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Acquisition
  • Angiography
  • Blood Vessels
  • Cancer
  • Detection
  • Detectors
  • Digital Images
  • Electron Beams
  • Health Services
  • High Definition Television
  • High Resolution
  • Materials
  • Neoplasms
  • Particle Physics
  • Radiation
  • Synchrotron Radiation
  • X Rays

Fields of Study

  • Physics

Readers

  • Cardiovascular Physiology
  • Nanofabrication and Microfabrication.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology