Evaluation of a Recoil-Escape Fiber Target Using 94Mo(p,n)94mTc to Produce 94TcO4- Precursor for Radiolabeled Compounds Useful in Positron Emission Tomography

Abstract

A variety of compounds radiolabeled with 99mTc(140 keV gamma T(sub 1/2)=6 hours) are widely used in nuclear medicine imaging. These compounds can also be radiolabeled using positron-emitting precursor 94mTcO4 (T(sub 1/2)=53 minutes) and used with Positron Emission Tomography (PET) to measure tissue concentrations in mu Ci/cm3, and produce kinetic data useful to understand the mechanism of drug action. This work-in-progress evaluates a novel accelerator target for producing 94mTc. Positron emitters have been produced with fiber targets, using the principle of recoil escape in which the target atoms are in a solid form, while recovering the product radionuclide ion by stopping it in a liquid or a gas. The recoil ion is transported out of the target, leaving the remaining target material to be used repeatedly in subsequent production runs. Our proposed target is based on this method.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA410506

Entities

People

  • B. W. Wieland
  • C. D. Illan

Organizations

  • Duke University Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Chemistry
  • Computer Programs
  • Energy
  • Geometry
  • Heat Transfer
  • Materials
  • Molybdenum
  • Nuclear Medicine
  • Nuclear Reactions
  • Positron Emission Tomography
  • Positron Emissions
  • Positrons
  • Production
  • Simulations
  • Technetium
  • Thermal Conductivity
  • Tomography

Fields of Study

  • Physics

Readers

  • Medical Imaging.
  • Molecular Photonics/Laser Physics
  • Systems Analysis and Design