Intermittent Ultrasound Imaging of Prostate Cancer
Abstract
This study proposed to evaluate contrast-enhanced ultrasound imaging with a microbubble contrast agent in 300 subjects over a period of 3 years in order to improve the detection of prostate cancer. Although the grant period began 8/1/2001, patient recruitment actually commenced on 10/1/2001. Between 10/15/2001 and 7/31/2002 a total of 103 subjects provided informed consent. Laboratory blood tests (PSA) and ultrasound evaluations were completed on all 103 subjects (including the ultrasound interpretation worksheet of the primary reviewer). An independent blinded reader has completed review of the first 47 subjects. Pathological review for the presence and grade of cancer has been completed for all 103 subjects. CD3l staining for microvissel density is in progress. Microvessel density counting will begin in August 2002. All available data has been entered into a computer database using an Excel spreadsheet. A preliminary analysis of the data from the first 56 subjects was incorporated into an abstract that has been accepted for presentation at the 60th annual meeting of the Mid-Atlantic section of the American Urological Association (see appendix). Based upon the current rate of recruitment (10 patients/month), study recruitment will require an additional 20 months. If the end date for the study is extended to 9/3l/04, the study protocol is progressing on target.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA410550
Entities
People
- Ethan J. Halpern
Organizations
- Thomas Jefferson University