Epidermal Growth Factor (EGF) Receptor Intron 1 CA Repeat Polymorphisms in African-American and Caucasian Males: Influence on Prostate Cancer Risk or Disease Progression and Interaction With Androgen Receptor CAG Repeat Polymorphisms
Abstract
We are investigating the effect of a polymorpkic epidermal growth factor receptor (EGFR) gene intron 1 CA repeat on prostate cancer (CaP) development, alone or in combination with a known androgen receptor gene CAG repeat polymorphism. We will determine the lengths of these repeats in DNA from African-American and Caucasian men with CaP. The data will be analyzed for any correlation using both parameters with clinical outcome (age of onset, rapid progression, or metastasis) . A biostatistician has been recruited to the study and a new statistical analysis plan has been developed. A major restructuring of the Cooper Hospital/ University Medical Center Institutional Review Board took place during the past year, and this resulted in a series of required changes in the informed consent form and other delays in obtaining documentation required for the revised human subjects protocol. Thus, the Human Subjects Protocol has not yet been approved by the US Army Medical Research and Materiel Command Human Subjects Research Review Board (USAMRMC HSRRB) . Since we have not been given approval to initiate the study, there is no data to report. However, the final pieces have recently come together, and a revised protocol has been submitted to the HSRRB.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA410564
Entities
People
- David K. Moscatello
Organizations
- Coriell Institute for Medical Research