Analysis of the Total Surgical Cardiac Denervation by Computer Simulation

Abstract

In this paper a new model for studying cardio-renal reflex dynamics has been introduced. Such models are important since by understanding cardio-renal dynamics well, better total artificial heart (TAH) implants may be designed and/or better drug treatment plans may be developed for helping TAH patients. The model introduced combines relevant parts of the two cardiovascular system models developed previously by Guyton et.al. A simulation of total surgical cardiac denervation (a condition which results in TAH implants), has resulted in an increase in the blood volume below the experimentally observed values. A correction of the kidney model including the effect of the renal sympathetic nerve activity on the set point of the tubulo-glomerular feedback mechanism is suggested.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA410627

Entities

People

  • A. Kayserilioglu
  • F. Karaaslan
  • H. O. Gulcur
  • Y. Denizhan

Organizations

  • Boğaziçi University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Angiotensin
  • Autonomous Systems
  • Biomedical Engineering
  • Birds
  • Blood
  • Blood Flow
  • Blood Volume
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Closed Loop Systems
  • Computer Simulations
  • Dynamics
  • Engineering
  • Feedback
  • Kidneys
  • Resistance
  • Simulations

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Computational Modeling and Simulation