Restoring BRCA1 Function With Antibiotics
Abstract
Inherited mutations in BRCA1 account for the majority of cancer cases in families with hereditary breast and ovarian cancer. Current evidence indicates that BRCA1 is involved in several cellular processes including transcriptional activation, cell cycle regulation, DNA damage repair and maintenance of genomic stability 2 Deleterious alterations in BRCA1 may result in disruption of any or all of these processes and lead to cancer. Missense, nonsense and frameshift mutations that disrupt the function of BRCA1 confer cancer predisposition to individuals carrying the mutation. Most of these mutations are highly penetrant and confer 56-85% lifetime risk for breast cancer, which is significantly higher than the 11% lifetime risk in the general population. Linkage analysis suggests that all mutations leading to premature termination of the protein documented so far will confer high cancer risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA410655
Entities
People
- Alvaro N. Monteiro