Assessment of the Tropicamide Concentration on Pupillary Response Test for Alzheimer's Disease

Abstract

Pupillary response test using a cholinergic antagonist, tropicamide was focused as a diagnostic method of Alzheimer's disease (AD). Ever since the test was reported, there have been studies that non-AD individuals showed same responses to tropicamide compared to AD individuals and that the test could not be useful for the diagnosis of AD. In this study, we changed the experimental conditions especially the tropicamide concentration, and proposed the new test under this condition. We made tropicamide half the concentration of the original test and performed the pupil test for non-AD subjects. We obtained the results that non-AD patients could not be hypersensitive to the new concentration of the eye drops. This could be helpful for the test to reduce the false positive rates.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA410707

Entities

People

  • Atsuhiko Iijima
  • Haruyuki Minamitani
  • Munetaka Haida
  • Norio Ishikawa
  • Yukito Shinohara

Organizations

  • Keio University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biomedical Engineering
  • Brain
  • Central Nervous System
  • Dementia
  • Detection
  • Diagnostic Imaging
  • Diseases And Disorders
  • Drop Tests
  • Engineering
  • Gray Scale
  • Image Processing
  • Images
  • Nervous System
  • Pilot Studies
  • Vascular Diseases
  • Video

Readers

  • Aerospace Research.
  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.