Green Tea in Prevention and Therapy of Prostate Cancer
Abstract
Epidemiological studies, though inconclusive suggest that drinking green tea may lower the risk of prostate cancer (CaP) in humans. Here we report that polyphenols present in green tea especially its major constituent (-) epigallocatechin- 3-gallate (EGCG) possesses both cancer preventive and cancer therapeutic properties. Our earlier studies reported in progress report of last year (Proc. Natl. Acad. Sci. USA 98:10350-5, 2001) using a transgenic adenocarcinoma of the mouse prostate (TRAMP), a model that mimics progressive forms of human prostatic disease, have shown that oral infusion of a polyphenolic fraction isolated from green tea at a human achievable dose (equivalent to six cups of green tea per day) significantly inhibited CaP development and progression. One significant observation from this study was that oral infusion of green tea polyphenols lead to increased cancer free and overall survival of these mice. Experiments conducted in this reporting period were conducted in athymic nude mice xenograft model implanted with androgen-sensitive 22Rv1 and androgen-insensitive PC-3 CaP cells. We found that intraperitoneal administration of EGCG resulted in significant inhibition in tumor growth and serum PSA levels. Importantly, mice treated with EGCG exhibited a marked decrease in tumor proliferation along with significant increase in apoptosis of both types of cancer cells. These data imply that EGCG can retard the growth of human CaP cells in the widely accepted xenograft model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA410754
Entities
People
- Sanjay Gupta
Organizations
- Case Western Reserve University