Potentiated Reinstatement of Cocaine-Seeking Behavior Following Amphetamine Infusion into the Basolateral Amygdale
Abstract
Rationale: Reinstatement of extinguished drug-seeking behavior following chronic drug self- administration has been demonstrated in rats in the presence of conditioned cues. We have previously shown that blockade of dopamine (DA) Dl receptors in the basolateral amygdala (B LA) abolishes conditioned cue-induced reinstatement of cocaine-seeking behavior. Objective: The present study tested the hypothesis that d-amphetamine-induced facilitation of monoamine neurotransmission in the BLA would facilitate conditioned cue-induced reinstatement of extinguished drug-seeking behavior. Methods: During daily self-administration sessions over 10 consecutive days, rats pressed a lever to receive cocaine infusions (0.2 mg/0.05 ml) paired with a tone+light compound stimulus. Following self-administration, rats underwent daily extinction sessions, during which no stimuli were presented. On the test days, rats received intra-BLA d- amphetamine (10 or 30 micro g/side) or vehicle infusions followed by extinction and conditioned cue- induced reinstatement testing. Results: D-amphetamine infusions did not alter extinction responding relative to vehicle infusions. During reinstatement testing, conditioned-cue presentation significantly increased responding over extinction levels, and intra-BLA d- amphetamine produced a dose-dependent increase in responding relative to vehicle infusions. Conclusion: These findings suggest that enhanced monoamine tone in the BLA potentiates the motivational effect and/or salience of cocaine-paired cues during reinstatement.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA410779
Entities
People
- Christopher C. Ledford
Organizations
- Air Force Institute of Technology