Tropomyosin-1, a Novel Class II Tumor-Suppressor and a Biomarker of Human Breast Cancer
Abstract
Actin microfilaments are critical for normal growth and differentiation. Normal cell morphology is maintained and regulated by actin microfilaments. The presence of disorganized or poorly structured microfilaments is a prominent feature of many transformed cells. In addition, microfilaments regulate cell division, cell motility and intracellular transport. Downregulation of microfilament-associated proteins, such as tropomyosins (TMs) is hypothesized to result in the formation of functionally aberrant microfilaments, thus contributing to the manifestation of the malignant cells. Previous studies from this laboratory have identified that: 1) Tropomyosin-1 (TM1) is a suppressor of the transformed phenotype, and; 2) TMl is consistently abolished in a large number of breast carcinoma cells that are tested. The main objectives of the proposed research are to assess the expression of TM1 in the tissue specimens of breast cancer patients and to investigate whether TM1 functions as a suppressor of the malignant growth of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA410784
Entities
People
- Gaddamanugu L. Prasad
Organizations
- Wake Forest University