Fluorescent Heterogeneities in Turbid Media: Limits for Detection With Dual-Interfering Sources Excitation
Abstract
A quantitative comparison between the single source and the dual-interfering sources configurations for the detection of fluorescent heterogeneities embedded in a piecewise highly scattering homogeneous fluorescent background was carried out. The study is based upon simulations using analytical solutions of the frequency domain diffuse photon density waves and practical signal-to-noise ratio considerations. Results show that the dual-interfering sources outperformed single source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast. To detect the same inhomogeneity, less concentration and lifetime contrast are required with dual-interfering sources.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 25, 2001
- Accession Number
- ADA410790
Entities
People
- B. Chance
- X. Intes
- Xingde Li
- Yu Chen
Organizations
- University of Pennsylvania