Identification of Potential Biomarkers for the Early Diagnosis of Breast Cancer
Abstract
The successful treatment of breast cancer requires detection of the disease at early stages. Currently the diagnostic tools for breast cancer suffer from drawbacks. In this application, we propose to systematically isolate a panel of secreted and cell surface proteins (trafficked proteins) that are over-expressed in early stage breast tumors, using a novel secretion trap strategy and cDNA micro-array. These proteins are candidates for blood-borne markers and cell surface markers that can be used in the early diagnosis of breast cancer. It is conceivable that multiple blood-borne markers, when used in combination, could predict the existence of tumors more accurately and more successfully. Once the presence of a tumor is predicted, cell surface markers can be used in imaging analysis to identify the location of the lesion. During the first year of the finding period, we have constructed a secretion trap library from multiple breast tumors, and have started the screen to isolated cDNA encoding trafficked proteins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA410809
Entities
People
- Peiqing Sun
Organizations
- Scripps Research