Non-Invasive Screening for Breast Cancer Biomarkers in Nipple Aspirates by Mass Spectrometry

Abstract

The three challenges that we faced before are: 1. To consistently differentiate peak differences in NA detected by Surface-Enhance Laser Desorption/Ionization (SELDI) between the two groups of women: breast cancer vs. non- cancer. 2. To identify and characterize the peak proteins that are differentially expressed in cancerous and non-cancerous NA. 3. To develop software program that can consistently identify the true peak from noise and quantify the intensity of each peak in a reproducible fashion.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA411257

Entities

People

  • Helena R. Chang

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • California
  • Electronic Mail
  • Information Operations
  • Intensity
  • Mass Spectrometry
  • Molecular Weight
  • Neoplasms
  • Observation
  • Protein Sequence Analysis
  • Spectrometry
  • Statistical Analysis

Readers

  • Acoustics.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Directed Energy