Fas/FasL System in c-Myc Expressing Mammary Carcinoma Cells

Abstract

The c-myc oncogene is thought to play an important role(s) in the onset and progression of breast cancer, where it is amplified in approximately 15% and overexpressed in over 60% of human breast cancers. Depending upon the availability of survival factors, cells that constitutively express c-Myc undergo proliferation, growth arrest, or apoptosis through as yet poorly defined mechanisms. Currently the molecular mechanism by which c-Myc sensitizes cells to apoptosis is not fully understood, nor are the environmental conditions in c-Myc-overexpressing mammary epithelium that promote apoptosis versus proliferation and transformation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA411302

Entities

People

  • Christine M. Coticchia
  • Robert B. Dickson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Epithelial Cells
  • Health Services
  • Lymphocytes
  • Mammary Glands
  • Neoplasms
  • Programmed Cell Death
  • Tumor Cell Line

Readers

  • Molecular Biology and Genetics