The Role of Notch in Regulating Apoptosis in the Mammary Gland

Abstract

This proposal is designed to explore the premise that Notch4 signaling may regulate apoptosis in the mammary gland. The specific aims are 1) to determine if nuclear hormone receptors interact with Notch; 2) to determine the functional role of Notch and nuclear hormone receptors in tumor formation: 3) to elucidate the signaling pathways influenced by potential interactions between Notch and nuclear hormone receptors. We have made significant progress towards understanding the crosstalk between Notch and some of the more important nuclear hormone receptors in the mammary gland.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA411402

Entities

People

  • Barbara A. Osborne

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Apoptosis
  • Biomedical Research
  • Cell Line
  • Cells
  • Epithelial Cells
  • Estrogens
  • Glands
  • Growth Factors
  • Hormones
  • Hybrid Systems
  • Mammary Glands
  • Mutations
  • Neoplasms
  • Progesterone
  • Proteins
  • Terminals

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics