The Structural Basis for the Role of CHK as a Tumor Suppressor Protein in Human Breast Cancer

Abstract

The goal of this project is to determine how CHK functions at the molecular level, crystals of the closed and purified, recombinant CHK SH2 domain will be obtained for X-ray diffraction studies from which we can determine its precise, three-dimensional, molecular Structure. Our research will focus upon the structural details of how CHK recognizes the tail of the active Her-2/neu receptor.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2002
Accession Number
ADA411428

Entities

People

  • Gordon D. Webster
  • Jerome E. Groopman

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Crystal Structure
  • Crystals
  • Electronic Mail
  • Fungi
  • Information Operations
  • Molecular Structure
  • Neoplasms
  • Structural Analysis
  • Suppressors
  • Three Dimensional
  • X Rays
  • X-Ray Diffraction

Readers

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  • Materials Science and Engineering.
  • Molecular Genetics