Novel Strategies for the Identification and Characterization of Selective Estrogen Receptor Modulators (SERMs)

Abstract

Estrogens promote growth of certain breast and endometrial cancers. Selective estrogen receptor modulators -- (SERMs), ligands that block the activity of estrogen in only selective tissues, allow to control the growth of these cancers while avoiding the many unwanted side effects associated with the use of antiestrogens. The goal of our work is to identify the mechanisms that control the activity of SERMs and to develop efficient high-throughput strategies for their identification.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2002
Accession Number
ADA411493

Entities

People

  • Beatrice D. Darimont
  • C. Pullen
  • G. Kouzmitscheva
  • J. Goodley
  • L. Getubig

Organizations

  • University of Oregon

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Chemical Compounds
  • Chemistry
  • Cysteine
  • Energy Transfer
  • Estrogens
  • Fluorescence
  • Hormone Antagonists
  • Hormones
  • Identification
  • Modulators
  • Molecular Biology
  • Students

Readers

  • Breast cancer cell signaling and growth regulation.