Computer Simulation of Electrical Propagation in Cardiac Tissue
Abstract
The purpose of the present research is to analyze the behavior of the reentrant spiral wave, which is one of the main causes of sudden cardiac death using computer simulation models of cardiac excitation propagation, The simulation model is a two dimensional electric circuit network model where many electric circuit models of cardiac membrane action potential were connected with electric resistance standing for intra-and extra cellular conductance, As cardiac membrane action potential model, we used Beeler-Reuter (B-R) model and Luo-Rudy (L-R) model, In order to investigate the effect of ionic current modification by anti-arrhythmic drugs on the reentrant pattern, we controlled the sodium current, I(sub Na), and the potassium current, I(sub K1), of the cardiac action potential models and investigated the obtained reentrant patterns, In order to validate the simulation results, we are comparing the reentry pattern under dose of anti-arrhythmic drugs observed by a high-resolution optical mapping system,
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 25, 2001
- Accession Number
- ADA411533
Entities
People
- A. Mishima
- E. Kobayashi
- H. Inada
- I. Sakuma
- T. Arafune
Organizations
- University of Tokyo