Wave Reflection and Characteristic Impedance in the Conscious Dog as Influenced by Adrenergic Intervention

Abstract

The combined measurement of aortic root pressure, flow and diameter permits determination of e.g. arterial compliance (C) and characteristic impedance (Zo). These systemic circulatory properties reflect the dynamic load to the left ventricle. Obviously, it is of clinical interest to study possible effects of cardiopharmacologic intervention on C and Zo. Therefore, the specific aims of this study are first to delineate the characteristics of the systemic circulation and second to analyze the influence of adrenergic agonists and blockers on C and Zo. We investigate these questions in the chronically instrumented dog by analyzing in particular effects of alpha and beta adrenergic drugs. We found that on average Zo amounts to 0.11 mmHg.s/ml, while medetomidine (by a rise of approximately 70%) causes the largest increase in Zo.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA411637

Entities

People

  • Jiang Li
  • P. Kerkhof

Organizations

  • Vrije Universiteit Amsterdam

Tags

Communities of Interest

  • Sensors

DTIC Thesaurus Topics

  • Abstracts
  • Arteries
  • Classification
  • Data Sets
  • Dynamic Loads
  • Electronic Mail
  • Engineering
  • Enzyme Inhibitors
  • Impedance
  • Intervention
  • Measurement
  • Military Research
  • Physics
  • Reflection
  • Time Domain
  • Ventricles
  • Waves

Readers

  • Aerospace Propulsion Engineering.
  • Neuroscience
  • Toxicology/Environmental Toxicology