Preclinical Mouse Models of Neurofibromatosis

Abstract

This is the final report for a two year award made to a Consortium of investigators who are working together to develop, characterize and utilize strains of mice that accurately model tumors that develop in persons with NF1 and NF2. This Consortium accomplished its primary goal of generating and characterizing mouse models of NF1 and NF2 associated tumors for biologic and preclinical therapeutic trials. A number of novel strains were developed, and shared widely with the research community.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2002
Accession Number
ADA411721

Entities

People

  • Andrea I McClatchey
  • Kevin Shannon
  • Luis F. Parada
  • Marco Giovannini
  • Tylr Jacks

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Blood
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Genetics
  • Leukocytes
  • Medical Personnel
  • Neoplasms
  • Nervous System Diseases
  • Nervous System Neoplasms
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Sarcoma

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Immunology and Pathology
  • Neurological Diseases/Conditions/Disorders