USF-1 as an Inhibitor of Mammary Gland Carcinogenesis
Abstract
The hypothesis tested in these studies is that overexpression of USF in the mammary glands of transgenic mice will inhibit myc-dependent tumorigenesis. Expression of a FLAG-tagged form or USF-2 was targeted to the mammary gland under the control of the mouse mammary tumor virus (mmtv) long terminal repeat. Of eight lines of transgenic mice that were generated, one demonstrated expression of flag-tagged USF-2 in the lactating mammary gland at levels 12-fold over that of endogenous USF-2. Evaluation of tumorigenesis in these mice (n=17) out to 453 days of age suggests that USF-2 when overexpressed by itself is not oncogenic. In contrast, 72% of mmtv-myc mice (n=18) analyzed have developed mammary tumors with an average latency of 156+/-33 days.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA411741
Entities
People
- Darryl L. Hadsell
Organizations
- Baylor College of Medicine