Breast Tumor pH: Design Evaluation and Application of Novel Reporter Molecules
Abstract
Systemic drugs are one of the most potent means for controlling breast cancer. Their ability to kill cancer cells often depends, however, on the presence of appropriate physiological conditions. For instance, exciting recent results suggest that uptake and retention of 5-fluorouracil (5-FU) in tumors may be influenced by pH, in particular, the trans membrane pH gradient. This opens the possibility of predicting which tumors will show best response by measuring pH a priori or modulating tumor physiology to optimize tumor selectivity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA411792
Entities
People
- Ralph P. Mason
Organizations
- University of Texas at Dallas