The Role of Steroid Receptor Coactivators (SRCs) in the Development of Prostate Cancer
Abstract
In prostate cancer, androgen receptor (AR) supervises several key genes expressions. In the cell. AR exerts its regulatory control on a target cell only in the presence of its cognate ligand, androgen. The regulatory functions of AR are more complex and are fine-tuned by accessory proteins. These proteins are required for the maximum biological impact by androgen. These modulators, called coactivators, provide a positive stimulus for receptor action. Our laboratory has cloned the first nuclear receptor coactivators such as SRC-1, -2, and -3. They have the capacity to activate the transcriptional activity of steroid receptor. However, the role of steroid receptor coactivators in prostate gland is still unclear.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA411955
Entities
People
- Jang H. Cho
Organizations
- Baylor College of Medicine