The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma

Abstract

Prostate cancer is one of the leading causes of cancer-related deaths in the United States and a leading - diagnosed cancer in American men. Newly diagnosed cases of prostate cancer approach rapidly the number of 200, 000 cases per year. Genetic alterations of tumor suppressor genes are one of the most common causes of prostate cancer tumorigenesis. Our group identified Hssh3bp1 as a candidate prostate tumor suppressor gene. In this research we are testing the tumor suppressor function of the candidate gene in pro static adenocarcinoma using in vitro and in vivo assays. Expression of Hssh3bp1 significantly decreased growth of LnCAP cells in vitro suggesting that Hssh3bp1 may be critical for regulation of growth of prostate tissue.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA411959

Entities

People

  • Jiliu Xu
  • Jill Macoska
  • Leszek Kotula
  • Magdalena Martinka
  • Piotr Kozlowski

Organizations

  • Research Foundation For Mental Hygiene

Tags

DTIC Thesaurus Topics

  • Adenocarcinoma
  • Biomedical Research
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Media
  • Cultured Cells
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Tumor Cell Line
  • United States

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology