Functional Analysis of TGF-alpha/beta Regulated Protein (TGFRP) in Breast Cancer Angiogenesis

Abstract

Angiogenesis is critical for tumor growth, maintenance, and metastasis. Tumors with no vascular bed are small, necrotic, and incapable of intravasation and hematogenous transport. Therapeutic strategies targeting vascularization promise efficacy against all types of solid tumors, including breast cancers. Preliminary studies of the novel secreted protein TGFRP suggest that it is an important angiogenic factor, implicated in tumor vascularization, progression, and metastasis. The aim of this project is to elucidate the role of TGFRP in carcinogenesis by studying expression in normal development, inappropriate expression in tumors, and effects upon cultured endothelial cells.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA412099

Entities

People

  • Ryan M. Anderson

Organizations

  • Duke University Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Angiogenesis
  • Artificial Intelligence
  • Biomedical Research
  • Blood Vessels
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Endothelial Cells
  • Functional Analysis
  • Molecules
  • Neoplasms
  • Proteins
  • Survival
  • Tumor Cell Line
  • Wound Healing

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).