Optical Coherence Tomography of the Breast: A Feasibility Study
Abstract
Optical Coherence Tomography (OCT) is a new high-resolution imaging modality utilizing near-infrared light waves that can perform cross-sectional, real time, non-invasive images at or near the cellular level in tissue. Optical biopsies taken up to a depth of 2-3 mm can achieve transverse resolution as high as 10 microns. This novel imaging technology has the potential to improve breast cancer detection and diagnosis. The aim of this study was to determine the feasibility of applying OCT imaging to normal and pathologic human breast tissue. OCT imaging failed to provide adequate differential tissue contrast to accurately characterize normal human breast tissue. Although certain architectural changes like stromal hyperplasia and fat necrosis were detected with optical biopsy, OCT imaging failed to identify (1) benign, pre-malignant and neoplastic epithelial changes as well as (2) stromal changes like granulation tissue, microcalcifications and desmoplasia. We are currently improving the OCT technology and additional specimens will be analyzed_
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412303
Entities
People
- James Fujimoto
- James L. Connolly
- Liron Pantanowitz
- Paul Herz
- Sughra Raza
Organizations
- Beth Israel Deaconess Medical Center