Dynamics of Estrogen Receptor Transcription Complex Assembly in Breast Cancer

Abstract

Estrogen plays a critical role in the development and progression of breast cancer. While endocrine therapies play an important part in breast cancer treatment, the failure of these therapies reflects a lack of knowledge concerning the molecular mechanisms involved in estrogen signaling. The biological activities of estrogen are mediated by estrogen receptors (ER) . In addition, a large number of proteins termed cofactors are involved in ER signaling. Until recently, our knowledge regarding these cofactors was based on their ability to bind receptors in vitro and affect transcriptional activation in transfection experiments. The in vivo role of these cofactors and the specific target genes involved in breast cancer are not well known.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA412699

Entities

People

  • Eli Hesterman
  • Myles A. Brown
  • Yongfeng Shang

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Assembly
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Dynamics
  • Estrogens
  • Gene Expression
  • Health Services
  • Hormones
  • Indicator Dyes
  • Neoplasms
  • Tumor Cell Line
  • Uterine Cancers

Fields of Study

  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.