Msx2 Plays a central Role in Regulating Branching Morphogenesis During Mammary Development
Abstract
The purpose of this study is to determine the role of a transcriptional factor, Msx2, in regulating branching events in the development of the mouse mammary gland To define the function of Msx2 gene in mammary gland development, we utilized targeted null mutants and transgenic animals, Besides a defect in elongation and branching in the null mutant mammary glands, we observed elongation and branching abnormalities associated with heterozygous null mutants which indicates that mammary glands development is sensitive to Msx2 gene dosage This is the first demonstration that mammary gland branching and elongation can be modulated by the level of gene expression of a homeodomain transcriptional factor,
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412700
Entities
People
- Yi-Hsin Liu
Organizations
- University of Southern California