Discovery of Novel Mammary Developmental and Cancer Genes Using ENU Mutagenesis
Abstract
Discovery of novel mammary developmental and cancer genes using ENU mutagenesis. The rate of death from breast cancer has only begun to fall in recent years To dramatically reduce breast cancer death rates we need new therapeutic targets, currently a major challenge facing cancer researchers This requires an understanding of the undiscovered pathways that operate to drive breast cancer cell proliferation, cell survival and cell differentiation, pathways which are also likely to operate during normal mammary development, and which go awry in cancer The discovery of signalling pathways operative in breast cancer has utilised examination of mammary gland development following systemic endocrine ablation or viral insertion, positional cloning in affected families and the investigation of genes identified in other tissues for activity in the mammary gland A systematic search for genes controlling mammary development and cancer will make these new targets available for new drug development To date there has been no systematic search for genes controlling mammary development. This project seeks to discover new genes involved in mammary gland carcinogenesis, by screening for mammary gland defects and tumors in the pedigrees produced by the large scale recessive ENU mutagenesis project at the John Curtin School Australian National University .
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412711
Entities
People
- Christopher J. Ormandy
Organizations
- Garvan Institute of Medical Research