Studies of Vascular Endothelial Growth Factor (VEGF) Signaling in Breast Cancer Cells

Abstract

Our proposal aims to investigate the function of VEGF in breast cancer cell growth and signaling. Our data suggest that breast cancer cells secrete various levels of VEGF and express in addition to the Flt-1 and Flk-1/KDR receptors, a novel VEGF receptor type which needs to be identified and characterized. These data lead us to hypothesize that VEGF, secreted by breast cancer cells, is a multi-functional protein which acts in an autocrine fashion and can simultaneously activate specific VEGF receptor signaling pathways in breast cancer cells, thereby regulating breast cancer cell growth, tumor angiogenesis and subsequently tumor growth.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA412712

Entities

People

  • Hava Avraham

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Intercellular Junctions
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).