Long Interspersed Nuclear Element (LINE) Mediated Genomic Instability
Abstract
The overall goals of this proposal are to isolate target oncogenes tumor suppressor genes and regions of chromosomal instability by the use of a long interspersed nuclear element based PCR assay We fully exploited the near completion of the human genome sequencing with bioinformatic tools to achieve our goals We targeted both known and novel genomic loci for potential candidate genes The first region was the c-Met oncogene, because of its association with poor prognosis in node negative breast cancer (1) The second line of investigations on a novel sequence specific single stranded DNA binding protein (SSBPs) stemmed from our parallel studies on human leukemia with poor prognosis Originally isolated in the chicken as a gene whose product binds pyrimidine rich mirror repeats elements the existence of three members that map regions of chromosomal instability was unknown until our studies uncovered this novel family.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA412752
Entities
People
- Lalitha Nagarajan
Organizations
- The University of Texas MD Anderson Cancer Center