Procathepsin D Stimulation of Human Breast Cancer Cell Growth

Abstract

The long-term objective of this project is to develop a new treatment for breast cancer based on blockade of the autocrine growth factor activity of procathepsin D, the enzymatically inactive precursor of common enzyme cathepsin D. This precursor has been found to be overexpressed and actively secreted from various breast tumor cells. For this project it is important to realize that the aspartic proteinase cathepsin D is generated by removal of an activation peptide (APpCD) from the procathepsin D molecule. In past, procathepsin D has been identified as an independent prognostic factor in several forms of cancer, particularly breast cancer. m

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2002
Accession Number
ADA412760

Entities

People

  • Vaclav Vetvicka

Organizations

  • University of Louisville

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Colon Cancer
  • Culture Media
  • Growth Factors
  • Medical Personnel
  • Oncology
  • Organic Chemistry
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Molecular and Cellular Biochemistry
  • Oncology and Biomarker-Based Cancer Detection.