Prostate stem Cell Antigen (PSCA): A Promising Marker and Therapeutic Target in Prostate Cancer

Abstract

PSCA is a cell surface antigen expressed in normal prostate, which was previously shown by our group to be overexpressed (when compared to expression in normal prostate) in a significant percentage (30-40%) of prostate cancers Our initial analysis suggested that PSCA expression might be higher in tumors of higher Gleason score and stage and in bone metastases The major goal of the current proposal was to establish prostate tissue arrays and test the hypothesis that PSCA expression could be used prognostically. We also wanted to see if PSCA could identify patients who might be candidates for anti- PSCA antibody therapy. Finally, we wanted to ask whether PSCA expression in bone marrow could identify patients at high risk to recur after initial therapy with prostatectomy.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2002
Accession Number
ADA412761

Entities

People

  • Robert E. Reiter

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antigens
  • Biological Staining And Labeling
  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cells
  • Diseases And Disorders
  • Neoplasms
  • Polymerase Chain Reaction
  • Prostate
  • Prostate Cancer
  • Stem Cells
  • Tissues

Fields of Study

  • Biology

Readers

  • Canine Service Warrior Training Program for Wounded Warriors in the Veterinary Industry, Supported by Donors.
  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech